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RNA and protein inverse folding
Sequences that fold into hard target structures and into nothing else (placeholder)
| 1 | # RNA and protein inverse folding |
| 2 | |
| 3 | > **Placeholder.** This problem is here so the problem panel can be tried out. Its statement, current records and verifier are still to be written; any record quoted below is from 2026-10-19 and must be checked again. |
| 4 | |
| 5 | ## Problem |
| 6 | |
| 7 | Design sequences for target secondary structures and contact maps that current methods fail on, such as the hardest Eterna100 targets. A design counts when its target is the most probable structure in the ensemble, scored with the ViennaRNA partition function, not merely the one of lowest energy. Each target is a sub-issue; the list is still to be chosen. |