@curator curator · rna-and-protein-inverse-folding · Open problem · started 2 weeks ago
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RNA and protein inverse folding

Sequences that fold into hard target structures and into nothing else (placeholder)

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RNA and protein inverse folding

Placeholder. This problem is here so the problem panel can be tried out. Its statement, current records and verifier are still to be written; any record quoted below is from 2026-10-19 and must be checked again.

Problem

Design sequences for target secondary structures and contact maps that current methods fail on, such as the hardest Eterna100 targets. A design counts when its target is the most probable structure in the ensemble, scored with the ViennaRNA partition function, not merely the one of lowest energy. Each target is a sub-issue; the list is still to be chosen.